Pathway name Database Link Note Classification Status Endothelin signaling pathway PANTHER http://www.pantherdb.org/pathway/pathwayList.do?searchType=basic&fieldName=all&organism=all&listType=8&fieldValue=prostaglandin Blood pressure/vascular tone Not Started Metabolism of angiotensinogen to angiotensins Reactome http://www.reactome.org/entitylevelview/PathwayBrowser.html#DB=gk_current&FOCUS_SPECIES_ID=48887&FOCUS_PATHWAY_ID=2022377&ID=2022377 Blood pressure/Vascular tone Done Vascular smooth muscle contraction KEGG http://www.genome.jp/kegg-bin/show_pathway?hsa04270 Blood pressure/Vascular tone Not Started Renin-angiotensin system KEGG http://www.genome.jp/kegg-bin/show_pathway?hsa04614 Blood pressure/Vascular tone Not Started eNOS activation and regulation Reactome http://www.reactome.org/entitylevelview/PathwayBrowser.html#DB=gk_current&FOCUS_SPECIES_ID=48887&FOCUS_PATHWAY_ID=202131&ID=203765 Blood pressure/Vascular tone Done Angiotensin II-stimulated signaling through G proteins and beta-arrestin PANTHER http://www.pantherdb.org/pathway/pathwayDiagram.jsp?catAccession=P05911 Blood pressure/Vascular tone Not Started Arachidonic Acid Metabolism KEGG http://www.kegg.jp/kegg-bin/show_pathway?map00590 Eicosanoid biosynthesis Done Eicosanoids Reactome http://www.reactome.org/entitylevelview/PathwayBrowser.html#DB=gk_current&FOCUS_SPECIES_ID=48887&FOCUS_PATHWAY_ID=211945&ID=211979 Eicosanoid biosynthesis Done Arachidonic Acid Metabolism Reactome http://www.reactome.org/entitylevelview/PathwayBrowser.html#DB=gk_current&FOCUS_SPECIES_ID=48887&FOCUS_PATHWAY_ID=2142753&ID=2142753 Eicosanoid biosynthesis Done COX reactions Reactome http://www.reactome.org/entitylevelview/PathwayBrowser.html#DB=gk_current&FOCUS_SPECIES_ID=48887&FOCUS_PATHWAY_ID=211945&ID=140180 Eicosanoid biosynthesis Done leukotriene biosynthesis Metacyc http://www.metacyc.org/META/NEW-IMAGE?type=PATHWAY&object=PWY66-375&detail-level=3 substrate = arachidonate Eicosanoid biosynthesis Not Started anandamide degradation Metacyc http://www.metacyc.org/META/NEW-IMAGE?type=PATHWAY&object=PWY6666-1 substrate = arachidonate Eicosanoid biosynthesis Not Started prostaglandin and leukotriene metabolism INOH http://www.inoh.org/download.html#PathwayData leukotriene Eicosanoid biosynthesis Not Started celecoxib pathway, pharmacodynamics PharmGKB http://www.pharmgkb.org/pathway/PA152241951 celecoxib NSAID PK/PD Not Started celecoxib pathway, pharmacokinetics PharmGKB http://www.pharmgkb.org/pathway/PA165816736 celecoxib NSAID PK/PD Not Started Naproxen PD pathway Small Molecule Pathway Database http://pathman.smpdb.ca/pathways/SMP00120/pathway?level=2 NSAID PK/PD Not Started Acetaminophen pathway Small Molecule Pathway Database http://www.pharmgkb.org/drug/PA448015#tabview=tab4&subtab=32 From Caroline NSAID PK/PD Not Started VEGF signaling pathway KEGG http://www.kegg.jp/kegg-bin/show_pathway?org_name=map&mapno=04370&mapscale=&show_description=hide Regulation of COX2 expression Not Started Inflammation mediated by chemokine and cytokine signaling pathway PANTHER http://www.pantherdb.org/pathway/pathwayList.do?searchType=basic&fieldName=all&organism=all&listType=8&fieldValue=prostaglandin Regulation of COX2 expression Not Started PI3 kinase pathway PANTHER http://www.pantherdb.org/pathway/pathwayDiagram.jsp?catAccession=P00048 Regulation of COX2 expression Not Started Toll receptor signaling pathway PANTHER http://www.pantherdb.org/pathway/pathwayList.do?searchType=basic&fieldName=all&organism=all&listType=8&fieldValue=prostaglandin Regulation of COX2 expression Not Started LPA receptor-mediated events NCI-PID http://pid.nci.nih.gov/search/pathway_landing.shtml?what=graphic&jpg=on&pathway_id=200013&source=NATURE&output-format=graphic&ppage=1 Regulation of COX2 expression Not Started Stabilization of mRNA by HuR Reactome http://www.reactome.org/entitylevelview/PathwayBrowser.html#DB=gk_current&FOCUS_SPECIES_ID=48887&FOCUS_PATHWAY_ID=450531&ID=450520 Regulation of COX2 expression Not Started Platelet homeostasis Reactome http://www.reactome.org/entitylevelview/PathwayBrowser.html#DB=gk_current&FOCUS_SPECIES_ID=48887&FOCUS_PATHWAY_ID=418346&ID=418346 Thrombosis/Platelet activation Not Started Factors involved in megakaryocyte development and platelet production Reactome http://www.reactome.org/entitylevelview/PathwayBrowser.html#DB=gk_current&FOCUS_SPECIES_ID=48887&FOCUS_PATHWAY_ID=983231&ID=983231 Used aspirin as search term Thrombosis/Platelet activation Not Started Platelet Aggregation Inhibitor Pathway, Pharmacodynamics PharmGKB http://www.pharmgkb.org/pathway/PA154444041 Used aspirin as search term Thrombosis/Platelet activation Not Started Platelet aggregation Reactome http://www.reactome.org/entitylevelview/PathwayBrowser.html#DB=gk_current&FOCUS_SPECIES_ID=48887&FOCUS_PATHWAY_ID=76009&ID=76009 Thrombosis/Platelet activation Not Started Platelet degranulation Reactome http://www.reactome.org/entitylevelview/PathwayBrowser.html#DB=gk_current&FOCUS_SPECIES_ID=48887&FOCUS_PATHWAY_ID=76005&ID=114608 Thrombosis/Platelet activation Not Started PPAR signaling pathway KEGG http://www.kegg.jp/dbget-bin/www_bget?map03320 signaling pathway Other Not Started Activation of Matrix Metalloproteinases Reactome http://www.reactome.org/entitylevelview/PathwayBrowser.html#DB=gk_current&FOCUS_SPECIES_ID=48887&FOCUS_PATHWAY_ID=1592389&ID=1592389 Used aspirin as search term Other Not Started Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs) Reactome http://www.reactome.org/entitylevelview/PathwayBrowser.html#DB=gk_current&FOCUS_SPECIES_ID=48887&FOCUS_PATHWAY_ID=381426&ID=381426 Used aspirin as search term Other Not Started PPARA activates gene expression Reactome http://www.reactome.org/entitylevelview/PathwayBrowser.html#DB=gk_current&FOCUS_SPECIES_ID=48887&FOCUS_PATHWAY_ID=400206&ID=1989781 Other Not Started Eicosanoid ligand-binding receptors Reactome http://www.reactome.org/entitylevelview/PathwayBrowser.html#DB=gk_current&FOCUS_SPECIES_ID=48887&FOCUS_PATHWAY_ID=500792&ID=391903 Eicosanoid Done Ibuprofen PK PharmGKB In preparation by PharmGKB NSAID PK/PD Not Started Diclofenac PK PharmGKB In preparation by PharmGKB NSAID PK/PD Not Started Acyl chain remodelling of PC Reactome http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=1482788 AA remodeling Not Started G alpha (s) signalling events Reactome http://www.reactome.org/entitylevelview/PathwayBrowser.html#DB=gk_current&FOCUS_SPECIES_ID=48887&FOCUS_PATHWAY_ID=388396&ID=418555 Signaling Not Started G alpha (i) signalling events Reactome http://www.reactome.org/entitylevelview/PathwayBrowser.html#DB=gk_current&FOCUS_SPECIES_ID=48887&FOCUS_PATHWAY_ID=388396&ID=418594 Signaling Not Started G alpha (q) signalling events Reactome http://www.reactome.org/entitylevelview/PathwayBrowser.html#DB=gk_current&FOCUS_SPECIES_ID=48887&FOCUS_PATHWAY_ID=388396&ID=416476 Signaling Not Started