Human gene name human protein (UniProt ID) human protein (NCBI Gene ID) OrthoMCL family Mouse ortholog/analog (gene name|NCBI ID) Evidence code (mouse) Notes (mouse) Rat ortholog/analog (gene name|NCBI ID) Evidence code (rat) Notes (rat) Fish ortholog/analog (gene name|NCBI ID) Evidence code (fish) Notes (fish) Yeast ortholog/analog (standard name|ORF) Evidence code (yeast) Notes (yeast) ABCC1 P33527 4363 OrthoMCL33 Abcc1|17250 1 Abcc1|24565 1 abcc1|100002010 2 YCF1|YDR135C 6 There are 4 homologs in P-POD (which appear to be paralogs due to reciprocal loss), including the 2 analogs, but YCF1 has the better p-value. ABCC4 O15439 10257 OrthoMCL33 Abcc4|239273 2 Abcc4|170924; RGD1565953|306166 2 RGD1565953 is very close to Abcc4 on chromosome 15q24. abcc4|368620 2 YOR1|YGR281W 2 ACAD9 Q9H845 28976 OrthoMCL4052 Acad9|229211 1 Acadvl|25363 2 Acadvl is a paralog of ACAD9 and is orthologous to human ACADVL acad9|724002 1 none 7 ACAT1 P24752 38 OrthoMCL331 Acat1|110446 1 Acat1|25014 1 acat1|445290 1 DGA1/YOR245C 9 PMID: 11751875 makes TAG from DAG along with LRO1/YNR008W ACOT1 Q86TX2 641371 OrthoMCL1037 Acot1|26897; Acot2|171210 6 Human ACOT1 and ACOT2 are close paralogs and share all the same orthologs. All four analogs have the same p-value. Acot1|50559 5 Human ACOT1 and ACOT2 are close paralogs and share all the same orthologs. All four analogs have the same p-value. none 7 All fish proteins in P-POD are either fragments or have been deprecated. none 7 ACOT11 Q8WXI4 26027 OrthoMCL9837 Acot11|329910 1 Acot11|100363074 1 acot11a|554842 2 none 7 ACOT13 Q9NPJ3 55856 OrthoMCL1915 Acot13|66834 1 Acot13|291135 2 acot13|564010 2 none 7 ACOT2 P49753 10965 OrthoMCL1037 Acot1|26897; Acot2|171210 6 Human ACOT1 and ACOT2 are close paralogs and share all the same orthologs. All four analogs have the same p-value. Acot1|50559; Acot2|192272 6 Human ACOT1 and ACOT2 are close paralogs and share all the same orthologs. Acot1 is a better analog than Acot2, but the difference is minor. none 7 none 7 ACOT4 Q8N9L9 122970 Para3210 Acot4|171282 1 Acot3|314304; Acot4|681337; Acot5|503049 6 In P-POD OrthoMCL23549, human ACOT4 has no rat homolog; in the MultiParanoid analysis, hACOT4 is paralogous to rat Acot2, -3, -4, and -5, but rAcot2 is orthologous to hACOT1 and -2. none 7 No orthologs in OrthoMCL; all 3 MP orthologs are fragments or have been deprecated. none 7 ACOT7 O00154 11332 OrthoMCL8596 Acot7|70025 2 Acot7|26759 2 acot7|447878 2 none 7 ACOT8 O14734 10005 OrthoMCL1816 Acot8|170789 2 Acot8|170588 2 acot8|450052 2 TES1|YJR019C 2 Looks like a paralog due to reciprocal loss, but function and compartment match. ACSL1 P33121 2180 OrthoMCL615 Acsl1|14081 1 Acsl1|25288 1 acsl1b/Zgc:101071|445175;acsl1|555308 8 In IMP, zgc:101071 has a better p-value (4e-12) than fish acsl1 (9e-5). FAA1|YOR317W;FAA4|YMR246W 9 PMID: 22633490; functional complementation:human gene ACSL1 restored Sph-to-glycerolipid conversion to faa1 faa4 double mutant ACSL3 O95573 2181 OrthoMCL505 Acsl3|74205 1 Acsl3|114024 1 acsl3a|567157;acsl3b|559656 2 FAA1|YOR317W;FAA3|YIL009W 8 A third ortholog, FAA4, has a much weaker p-value. ACSL4 O60488 2182 OrthoMCL505 Acsl4|50790 1 Acsl4|113976 1 acsl4a|393622 1 FAA1|YOR317W;FAA3|YIL009W;FAA4|YMR246W 8, 9 A third ortholog, FAA4, has a much weaker p-value.; PMID:24269233 human gene ACSL4 complemented the deficient SPH-to-glycerophospholipid metabolism in Δfaa1 Δfaa4 cells ACSL5 Q9ULC5 51703 OrthoMCL615 Acsl5|433256 1 Acsl5|94340 1 none 7 There are fish genes in the same OrthoMCL family, but they are paralogous to ACSL5 and orthologous to other human genes. none 7, 9 The closest yeast gene, FAA2, is paralogous to ACSL5 and is a medium-, not a long-chain, synthase.; PMID:24269233 human gene ACSL5 complemented the deficient SPH-to-glycerophospholipid metabolism in Δfaa1 Δfaa4 cells ACSL6 Q9UKU0 23305 OrthoMCL615 Acsl6|216739 1 Acsl6|117243 1 acsl6|566863 2 FAA1|YOR317W;FAA4|YMR246W 9 PMID: 22633490; functional complementation:human gene ACSL6 restored Sph-to-glycerolipid conversion to faa1 faa4 double mutant AGPAT2 O15120 10555 OrthoMCL9777 Agpat2|67512 1 Agpat2|311821 1 none 7 none 7 AGPAT4 Q9NRZ5 56895 OrthoMCL8505 Agpat4|68262 1 Agpat4|170919 1 agpat4|406265 2 none 7 AGPAT5 Q9NUQ2 55326 OrthoMCL6334 Agpat5|52123 1 Agpat5|306582 2 agpat5|767778 2 none 7 AKR1B1 P15121 231 OrthoMCL131 Akr1B3|11677 1 Akr1b1|24192 1 akr1b1|415138 1 Also orthologous to hAKR1B10. none 7 AKR1C3 P42330 8644 OrthoMCL7458 Akr1c6|83702 6 IMP identified 3 different proteins with p=1e-3. Akr1c1|307092 6 Four human paralogs (AKR1C1, -2, -3, and -4) are orthologous to rat Akr1c1. none 7 none 7 ALOX12 P18054 239 OrthoMCL4377 Alox12|11684 1 Mouse has several other genes with similar names, but this one is the ortholog/analog. Alox12|287454 1 alox12|322732 1 Zebrafish alox12 is orthologous to hALOX12 and hALOX15. none 7 ALOX12B O75342 242 OrthoMCL397 Alox12b|11686 2 Alox12b|287425 1 none 7 Closest zebrafish genes are paralogous to ALOX12B and more closely related to LOX5. none 7 ALOX15 P16050 246 OrthoMCL4377 Alox15/Alox12l|11687 2 Alox15|81639 1 alox12|322732 2 Zebrafish alox12 is orthologous to hALOX12 and hALOX15. none 7 ALOX15B O15296 247 OrthoMCL397 Alox8|11688 1 Alox15b|266604 1 none 7 none 7 ALOX5 P09917 240 OrthoMCL397 Alox5|11689 1 Alox5|25290 1 alox5|567204 2 none 7 ALOX5AP P20292 241 OrthoMCL11158 Alox5ap|11690 1 Alox5ap|29624 1 alox5ap|337376 2 none 7 ALOXE3 Q9BYJ1 59344 OrthoMCL397 Aloxe3|23801 1 Aloxe3|287424 1 none 7 Closest zebrafish genes in P-POD correspond to hALOX5. none 7 AWAT2 Q6E213 158835 OrthoMCL17640 Awat2|245532 1 Awat2|302425 1 none 7 none 7 BAAT Q14032 570 OrthoMCL17645 Baat|12012 1 Baat|29725 1 none 7 none 7 CBR1 P16152 873 OrthoMCL1165 Cbr1|12408 2 Cbr1|29224 2 cbr1|373866;cbr1l|337696 2 Zebrafish cbr1 and cbr1l are orthologous to both human CBR1 and CBR3. A third ortholog listed in P-POD has been deprecated. none 7 CBR3 O75828 874 OrthoMCL1165 Cbr3|109857 1 Cbr3|304078 1 cbr1|373866;cbr1l|337696 2 Zebrafish cbr1 and cbr1l are orthologous to both human CBR1 and CBR3. A third ortholog listed in P-POD has been deprecated. none 7 CYP1A1 P04798 1543 OrthoMCL3 Cyp1a1|13076 1 Cyp1a1|24296 1 cyp1a|140634 1 Difficult to classify Cyp450 proteins. Zebrafish cyp1a is the closest paralog and the only IMP analog of human CYP1A1. Also, there appears to be a reciprocal loss in that clade of the OrthoMCL family, resulting in a presumptive duplication event with bird and fish genes forming one clade and mammalian genes another; if this reciprocal loss is not correct, then cyp1a would be an ortholog of CYP1A1. none 7 CYP1A2 P05177 1544 OrthoMCL3 Cyp1a2|13077 1 Cyp1a2|24297 2 cyp1a|140634 1 Difficult to classify Cyp450 proteins. Zebrafish cyp1a is paralogous to human CYP1A1 and CYP1A2. none 7 CYP1B1 Q16678 1545 OrthoMCL7204 Cyp1b1|13078 1 Cyp1b1|25426 2 cyp1b1|100150054 1 none 7 CYP2B6 P20813 1555 OrthoMCL2039 Cyp2b19|13090;Cyp2b9|13094 5 Difficult to classify Cyp450 proteins. Both P-POD and IMP agree on these five mouse genes: Cyp2b19 (NCBI GeneID 13090; p=5e-12), Cyp2b9 (NCBI GeneID 13094; p=3e-12), Cyp2b10 (NCBI GeneID 13088; p=2e-06), Cyp2b23 (NCBI GeneID 243881; p=6e-4), and Cyp2b13 (NCBI GeneID 13089; p=2e-3). Cyp2b1|24300 5 P-POD OrthoMCL identifies only paralogs. none 7 Difficult to classify Cyp450 proteins. none 7 CYP2C18 P33260 1562 OrthoMCL3 Cyp2c55|72082 2 Difficult to classify Cyp450 proteins. Cyp2c11|29277;Cyp2c24|499353;Cyp2c80|292330 2 Difficult to classify Cyp450 proteins. cyp2y3|368352 2 Difficult to classify Cyp450 proteins. Zebrafish cyp2y3 is orthologous to human CYP2C8, CYP2C9, CYP2C18, and CYP2C19. none 7 CYP2C19 P33261 1557 OrthoMCL3 Cyp2c66|69888;Cyp2c65|72303 3 Difficult to classify Cyp450 proteins. Cyp2c79|293985 3 Difficult to classify Cyp450 proteins. Cyp2c79 is paralogous to CYP2C19 and is also classified as an analog of CYP2C9. cyp2y3|368352 2 Difficult to classify Cyp450 proteins. Zebrafish cyp2y3 is orthologous to human CYP2C8, CYP2C9, CYP2C18, and CYP2C19. none 7 CYP2C8 P10632 1558 OrthoMCL3 Cyp2c55|72082 3 Difficult to classify Cyp450 proteins. Cyp2c11|29277 3 Difficult to classify Cyp450 proteins. Cyp2c11 is a paralog of CYP2C8 and is also classified as one of several orthologs/analogs of CYP2C18. cyp2y3|368352 2 Difficult to classify Cyp450 proteins. Zebrafish cyp2y3 is orthologous to human CYP2C8, CYP2C9, CYP2C18, and CYP2C19. none 7 CYP2C9 P11712 1559 OrthoMCL3 Cyp2c66|69888;Cyp2c65|72303 3 Difficult to classify Cyp450 proteins. Cyp2c79|293985 3 Difficult to classify Cyp450 proteins. Cyp2c79 is paralogous to CYP2C9 and is also classified as an analog of CYP2C19. cyp2y3|368352 2 Difficult to classify Cyp450 proteins. Zebrafish cyp2y3 is orthologous to human CYP2C8, CYP2C9, CYP2C18, and CYP2C19. none 7 CYP2D6 P10635 1565 OrthoMCL3 Cyp2d26|76279 5 Difficult to classify Cyp450 proteins. Mouse Cyp2d26 is the top-ranked analog (p=1e-11) and a close paralog of human CYP2D6. Other analogs include Cyp2d26 (NCBI GeneID 76279; p=1e-11), Cyp2d12 (NCBI GeneID 380997; p=4e-7), Cyp2d22 (NCBI GeneID 56448; p=4e-7), Cyp2d34 (NCBI GeneID 223706; p=4e-7), and Cyp2d40 (NCBI GeneID 71754; p=4e-7). P-POD names Cyp2d22 as the ortholog of CYP2D6. none 6 none 7 Difficult to classify Cyp450 proteins. none 7 CYP2E1 P05181 1571 OrthoMCL17893 Cyp2e1|13106 1 Cyp2e1|25086 1 none 7 none 7 CYP2J2 P51589 1573 OrthoMCL3 Cyp2j6 |13110 5 Difficult to classify Cyp450 proteins. Top-ranked analog (also an ortholog): Cyp2j6 (NCBI GeneID 13110; p=8e-10). Other analogs and orthologs identified include: Cyp2j5 (NCBI GeneID 13109; p=1e-4), Cyp2j9 (NCBI GeneID 74519; p=9e-4), Cyp2j11 (NCBI GeneID 100066; p=9e-4), Cyp2j13 (NCBI GeneID 230459), Cyp2j8 (NCBI GeneID 665095), and Cyp2j12 (NCBI GeneID 242546). Cyp2j16|502969 4 Difficult to classify Cyp450 proteins. cyp2n13|492484;cyp2p6|393108;cyp2p10|399485;cyp2p9|393592;cyp2v1|494153;cyp2ae1|572114;cyp2j20|797309;cyp2p7|100034406;cyp2p8|100034366 6 Difficult to classify Cyp450 proteins. There appears to have been rapid expansion of this gene in zebrafish; P-POD (OrthoMCL) lists 8 orthologs, which form a single clade of fish proteins. Four of these proteins (cyp2n13, cyp2p6, cyp2p10, and cyp2p9) are also listed as analogs in IMP. IMP also identifies a fifth, slightly weaker, analog, cyp2v1; this gene is orphaned in P-POD's OrthoMCL analysis, but identified as an ortholog of hCYP2J2 in P-POD's MultiParanoid analysis. Because the genes are so closely related, and because the analogs have comparable p-values, I am choosing the combined set of all nine proteins. none 7 CYP2U1 Q7Z449 113612 OrthoMCL17408 Cyp2u1|71519 3 Difficult to classify Cyp450 proteins. Cyp2u1|310848 1 cyp2u1|556280 2 Difficult to classify Cyp450 proteins. none 7 CYP3A4 P08684 1576 OrthoMCL21 Cyp3a11|13112;Cyp3a25|56388;Cyp3a41b|100041375;Cyp3a16|13114;Cyp3a59|100041449 5 Difficult to classify Cyp450 proteins. P-POD and IMP agree on the top five hits: Cyp3a11 (NCBI GeneID 13112; p=5e-12), Cyp3a25 (NCBI GeneID 56388; p=5e-12), Cyp3a41b (NCBI GeneID 100041375; p=6e-12), Cyp3a16 (NCBI GeneID 13114; p=2e-11), and Cyp3a59 (NCBI GeneID 100041449; p=7e-10). Four additional proteins are identified as either orthologs or analogs: Cyp3a57 (NCBI GeneID 622127), Cyp3a13 (NCBI GeneID 13113), Cyp3a41a (NCBI GeneID 53973), and Cyp3a44 (NCBI GeneID 337924). Cyp3a18|252931; Cyp3a2|266682 5 Difficult to classify Cyp450 proteins. These proteins, and several others, are also orthologous to human CYP3A7, CYP3A5, and CYP3A3. cyp3c1l2|492759;cyp3c4|558541 6 Difficult to classify Cyp450 proteins. P-POD identified one ortholog, cyp3a65 (NCBI GeneID 553969), which was the third-ranked of the 4 analogs identified by IMP: cyp3c1l2 (NCBI GeneID 492759; p=1e-6); cyp3c4 (NCBI GeneID 558541; p=3e-6); cyp3a65 (NCBI GeneID 553969; p=7e-5); cyp3c1 (NCBI GeneID 324340; p=4e-4). Curator chose the two top-ranked analogs. none 7 CYP4A11 Q02928 1579 OrthoMCL21 Cyp4a10|13117;Cyp4a31|666168;Cyp4a32|100040843 (9e-4) 5 Difficult to classify Cyp450 proteins. IMP identifies these three mouse proteins as the best analogs: Cyp4a10 (NCBI GeneID 13117; p=1e-05), Cyp4a31 (NCBI GeneID 666168; p=9e-4), and Cyp4a32 (NCBI GeneID 100040843; p=9e-4). P-POD also identifies the following as orthologs: Cyp4a12a (NCBI GeneID 277753), Cyp4a12b (NCBI GeneID 13118), Cyp4a14 (NCBI GeneID 13119), and pseudogene Cyp4a30b-ps (NCBI GeneID 435802). Cyp4a1|50549; Cyp4a2|24306; Cyp4a3|298423; Cyp4a8|266674 2 Difficult to classify Cyp450 proteins. These rat proteins are orthologous to both human CYP4A11 and CYP4A22. cyp4t8|387527 2 Difficult to classify Cyp450 proteins. Zebrafish cyp4t8 is also orthologous to several other human CYP450 proteins. none 7 CYP4A22 Q5TCH4 284541 OrthoMCL21 Cyp4a31|666168;Cyp4a32|100040843;Cyp4a10|13117 5 Difficult to classify Cyp450 proteins. IMP identifies these three mouse proteins as the best analogs: Cyp4a31 (NCBI GeneID 666168; p=3e-4), Cyp4a32 (NCBI GeneID 100040843; p=3e-4), and Cyp4a10 (NCBI GeneID 13117; p=3e-3). P-POD also identifies the following as orthologs: Cyp4a12a (NCBI GeneID 277753), Cyp4a12b (NCBI GeneID 13118), Cyp4a14 (NCBI GeneID 13119), and pseudogene Cyp4a30b-ps (NCBI GeneID 435802). Cyp4a1|50549; Cyp4a2|24306; Cyp4a3|298423; Cyp4a8|266674 2 Difficult to classify Cyp450 proteins. These rat proteins are orthologous to both human CYP4A11 and CYP4A22. cyp4t8|387527 2 Difficult to classify Cyp450 proteins. Zebrafish cyp4t8 is also orthologous to several other human CYP450 proteins. none 7 CYP4F11 Q9HBI6 57834 OrthoMCL21 Cyp4f15|106648;Cyp4f40|631304 2 Difficult to classify Cyp450 proteins. These mouse proteins are orthologous to human CYP4F2, CYP4F3, CYP4F8, and CYP4F11. Cyp4f1|56266; Cyp4f4|286904; Cyp4f40|503122 2 Difficult to classify Cyp450 proteins. These rat proteins are all orthologous to human CYP4F2, -3, -8, -11, and -12. cyp4f43|100037390 2 Difficult to classify Cyp450 proteins. This fish protein is orthologous to human CYP4F2, CYP4F3, CYP4F8, and CYP4F11. none 7 CYP4F2 P78329 8529 OrthoMCL21 Cyp4f15|106648;Cyp4f40|631304 2 Difficult to classify Cyp450 proteins. These mouse proteins are orthologous to human CYP4F2, CYP4F3, CYP4F8, and CYP4F11. Cyp4f1|56266; Cyp4f4|286904; Cyp4f40|503122 2 Difficult to classify Cyp450 proteins. These rat proteins are all orthologous to human CYP4F2, -3, -8, -11, and -12. cyp4f3|100037390 2 Difficult to classify Cyp450 proteins. This fish protein is orthologous to human CYP4F2, CYP4F3, CYP4F8, and CYP4F11. none 7 CYP4F22 Q6NT55 126410 OrthoMCL21 Cyp4f39|320997 1 Cyp4f39|299566 1 cyp4f43|100037390 2 Difficult to classify Cyp450 proteins. This fish protein is orthologous to human CYP4F2, CYP4F3, CYP4F8, and CYP4F11. none 7 CYP4F3 Q08477 4051 OrthoMCL21 Cyp4f15|106648;Cyp4f40|631304 2 Difficult to classify Cyp450 proteins. These mouse proteins are orthologous to human CYP4F2, CYP4F3, CYP4F8, and CYP4F11. Cyp4f1|56266; Cyp4f4|286904; Cyp4f40|503122 2 Difficult to classify Cyp450 proteins. These rat proteins are all orthologous to human CYP4F2, -3, -8, -11, and -12. cyp4f3|100037390 2 Difficult to classify Cyp450 proteins. This fish protein is orthologous to human CYP4F2, CYP4F3, CYP4F8, and CYP4F11. none 7 CYP4F8 P98187 11283 OrthoMCL21 Cyp4f15|106648;Cyp4f40|631304 2 Difficult to classify Cyp450 proteins. These mouse proteins are orthologous to human CYP4F2, CYP4F3, CYP4F8, and CYP4F11. Cyp4f1|56266; Cyp4f4|286904; Cyp4f40|503122 2 Difficult to classify Cyp450 proteins. These rat proteins are all orthologous to human CYP4F2, -3, -8, -11, and -12. cyp4f3|100037390 2 Difficult to classify Cyp450 proteins. This fish protein is orthologous to human CYP4F2, CYP4F3, CYP4F8, and CYP4F11. none 7 CYSLTR1 Q9Y271 10800 OrthoMCL11035 Cysltr1|58861 1 Cysltr1|114099 1 cysltr1|553675 1 none 7 CYSLTR2 Q9NS75 57105 OrthoMCL13915 Cysltr2|70086 1 Cysltr2|170926 1 none 7 none 7 DPEP1 P16444 1800 OrthoMCL1488 Dpep1|13479 2 Dpep1|94199 1 dpep1/zgc:153024|768195 2 none 7 DPEP2 Q9H4A9 64174 OrthoMCL1488 Dpep2|319446 4 Human DPEP2 is paralogous to both mouse Dpep2 and Dpep3. Dpep2|291984 4 Human DPEP2 is paralogous to both rat Dpep2 and Dpep3. none 7 none 7 ELOVL2 Q9NXB9 54898 OrthoMCL9713 Elovl2|54326 1 Elovl2|498728 1 elovl2|678614 1 none 7 No orthologs in OrthoMCL; all 3 MultiParanoid homologs are paralogs and orthologous to other human proteins. ELOVL5 Q9NYP7 60481 OrthoMCL9754 Elovl5|68801 1 Elovl5|171400 1 elovl5|393425 2 none 7 No orthologs in OrthoMCL; all 3 MultiParanoid homologs are paralogs and orthologous to other human proteins. EPHX2 P34913 2053 OrthoMCL1321 Ephx2|13850 2 Ephx2|65030 2 ephx2|494099 2 P-POD shows a duplication and reciprocal loss among the vertebrates--chicken and zebrafish are in one clade and human, mouse, and rat are in the other--but that may be incorrect. As a result, zebrafish ephx2, which P-POD shows as paralogous to hEPHX2, may actually be orthologous. YNR064C 9 PMID: 15769598; YNRO64C is homologous to the epoxide hydrolase portion of the mammalian EPHX2, the homology to the lipid phosphatase (lipase) function has not been investigated FADS1 O60427 3992 not in P-POD Fads1|76267 3 Protein not in P-POD. Fads1|84575 3 Protein not in P-POD. none 7 Protein not in P-POD. none 7 Human protein not present in P-POD input FADS2 O95864 9415 OrthoMCL1196 Fads2|56473 1 Fads2|83512 1 fads2|140615 1 none 7 FAM213B/C1ORF93 Q8TBF2 127281 OrthoMCL9743 Fam213b/2810405K02RIK|66469 1 Fam213b|362676 2 fam213b|406605 2 none 7 GGT1 P19440 2678 OrthoMCL507 Ggt1|14598 2 Ggt1|116568 2 P-POD OrthoMCL identifies 3 human genes orthologous to rat Ggt1 and paralogous to each other: GGT1, -2, and -3. ggt1a|393387;ggt1b|569014 2 ECM38|YLR299W 2 GGT5 P36269 2687 OrthoMCL14233 Ggt5|23887 2 Ggt5|29566 2 none 7 none 7 GGT6 Q6P531 124975 Para13465 Ggt6|71522 1P Ggt6|408206 1P none 7 none 7 GGT7 Q9UJ14 2686 OrthoMCL14358 Ggt7|207182 1 Ggt7|156275 1 none 7 none 7 GPR17 Q13304 2840 OrthoMCL11112 Gpr17|574402 1 Gpr17|767613 1 none 7 P-POD hit not a verified gene. none 7 GPX1 P07203 2876 OrthoMCL15298 Gpx1|14775 2 Gpx1|24404 2 gpx1a|352926 2 none 7 GPX2 P18283 2877 OrthoMCL18124 Gpx2|14776 2 Gpx2|29326 1 none 7 none 7 GPX3 P22352 2878 OrthoMCL13449 Gpx3|14778 1 Gpx3|64317 1 gpx3|798788 2 none 7 GPX4 P36969 2879 OrthoMCL610 Gpx4|625249 1 Gpx4|29328 2 gpx4a|352928 2 none 7 Yeast genes are distantly related and paralogs. GPX5 O75715 2880 OrthoMCL4858 Gpx5|14780 2 Gpx6|259233 2 Both human GPX5 and GPX6 are paralogous to rat Gpx6. none 7 none 7 GPX6 P59796 257202 OrthoMCL4858 Gpx6|75512 5 Human GPX6 is shown as paralogous to both mouse Gpx6 and Gpx5, but Gpx5 is orthologous to human GPX5. Gpx6|259233 2 Both human GPX5 and GPX6 are paralogous to rat Gpx6. none 7 none 7 GPX7 Q96SL4 2882 OrthoMCL10220 Gpx7|67305 1 Gpx7|298376 1 gpx7|552981 2 none 7 HPGD P15428 3248 OrthoMCL2467 Hpgd|15446 1 Hpgd|79242 1 LOC565975|565975 2 none 7 HPGDS O60760 27306 OrthoMCL137 Hpgds|54486 2 Hpgds|58962 1 none 7 none 7 LCAT P04180 3931 OrthoMCL14969 Lcat|16816 1 Lcat|24530 1 lcat|793137 2 LRO1/YNR008W 9 PMID: 10747858 makes TAG from DAG along with DGA1/YOR245C LIPA P38571 3988 OrthoMCL107 Lipa|16889 1 Lipa|25055 1 lipf|406713 2 Lipf is orthologous to 2 clades of mammalian genes. YEH1|YLL012W; YEH2|YLR020C; TGL1|YKL140W 9 PMID: 15713625 de-esterify sterol esters LIPE Q05469 3991 OrthoMCL8264 Lipe|16890 2 Lipe|25330 2 lipea|568368 2 none 7 LIPG Q9Y5X9 9388 OrthoMCL10476 Lipg|16891 1 Lipg|291437 1 lipg|393096 2 none 7 LPCAT1 Q8NF37 79888 OrthoMCL9733 Lpcat1|210992 1 Lpcat1|361467 1 lpcat1|555969 1 none 7 LPCAT2 Q7L5N7 54947 OrthoMCL5152 Lpcat2|270084 1 Lpcat2|100359680 2 lpcat2|553683 1 P-POD identifies lpcat2 as a paralog of hLPCAT2. none 7 LPCAT3 Q6P1A2 10162 OrthoMCL8055 Lpcat3|14792 1 Lpcat3|362434 1 none 7 none 7 LTA4H P09960 4048 OrthoMCL2313 Lta4h|16993 1 Lta4h|299732 1 lta4h|406575 1 none 7 Limited biochemical similarity to paralog LAP2/YNL045W. LTB4R Q15722 1241 OrthoMCL7043 Ltb4r1|16995 1 Ltb4r|59264 1 si:ch211-272h9.2|100317356;LOC100329657|100329657 2 none 7 LTB4R2 Q9NPC1 56413 OrthoMCL18321 Ltb4r2|57260 1 Ltb4r2|114098 1 none 7 none 7 LTC4S Q16873 4056 OrthoMCL6986 Ltc4s|17001 2 Ltc4s|114097 1 ltc4s|100535432 2 none 7 MAPKAPK2 P49137 9261 OrthoMCL8270 Mapkapk2|17164 1 Mapkapk2|289014 1 mapkapk2a|327321 1 none 7 MBOAT7 Q96N66 79143 OrthoMCL8239 Mboat7|77582 1 Mboat7|308309 1 mboat7|393509 1 none 7 MGST2 Q99735 4258 OrthoMCL10205 Mgst2 |211666 1 Mgst2|295037 1 mgst2|723997 2 none 7 MGST3 O14880 4259 OrthoMCL5385 Mgst3|66447 2 Mgst3|289197 2 mgst3|406736 1 Another ortholog has been deprecated. none 7 OXER1 Q8TDS5 165140 orphan (Jaccard4) none 1 none 7 none 1 none 1 PAFAH2 Q99487 5051 OrthoMCL2781 Pafah2|100163 1 Pafah2|313611 1 none 7 none 7 PLA2G10 O15496 8399 OrthoMCL6995 Pla2g10|26565 2 Pla2g1029359 1 none 7 none 7 PLA2G12A Q9BZM1 81579 OrthoMCL10465 Pla2g12a|66350 2 Pla2g12a|362039 2 pla2g12a|402802 2 none 7 PLA2G12B Q9BX93 84647 Para5884 Pla2g12b|69836 1P Pla2g12b|367415 2 pla2g12b|406739 2P none 7 PLA2G16 P53816 11145 OrthoMCL18155 Pla2g16|225845 2 Pla2g16|24913 1 none 7 There is 1 MultiParanoid ortholog, but it has been deprecated. none 7 PLA2G1B P04054 5319 OrthoMCL5761 Pla2g1b|18778 2 Pla2g1b|29526 1 pla2g1b|571738 2 none 7 PLA2G2A P14555 5320 OrthoMCL13845 Pla2g2a|18780 2 Pla2g2a|29692 1 none 7 none 7 PLA2G2D Q9UNK4 26279 OrthoMCL18593 Pla2g2d|18782 1 Pla2g2d|298579 1 none 7 none 7 PLA2G2E Q9NZK7 30814 OrthoMCL8981 Pla2g2e|26970 1 Pla2g2e|298581 2 none 7 none 7 PLA2G2F Q9BZM2 64600 OrthoMCL18594 Pla2g2f|26971 1 Pla2g2f|690388 1 none 7 none 7 PLA2G3 Q9NZ20 50487 OrthoMCL12124 Pla2g3|237625 2 Pla2g3|289733 1 zgc:123275|641423 2 none 7 PLA2G4A P47712 5321 OrthoMCL7255 Pla2g4a|18783 1 Pla2g4a|24653 1 pla2g4a|559087;cpla2|30554 2 none 7 PLA2G4B P0C869 100137049 OrthoMCL639 Pla2g4b|211429 1 Pla2g4b|311341 1 LOC565386|565386 2 LOC565386 is uncharacterized and is orthologous to several paralogous mammalian clades. none 7 PLA2G4C Q9UP65 8605 OrthoMCL3572 Pla2g4c|232889 1 Pla2g4c|691813 4 zgc:101699|492789 2 P-POD lists 3 more fish orthologs with ENSEMBL IDs, but they don't map to Gene IDs. none 7 PLA2G4D Q86XP0 283748 OrthoMCL639 Pla2g4d|78390 1 Pla2g4d|691905 1 LOC565386|565386 2 LOC565386 is uncharacterized and is orthologous to several paralogous mammalian clades. none 7 PLA2G4E Q3MJ16 123745 OrthoMCL639 Pla2g4e|329502 1 none 7 LOC565386|565386 2 LOC565386 is uncharacterized and is orthologous to several paralogous mammalian clades. none 7 PLA2G4F Q68DD2 255189 OrthoMCL639 Pla2g4f|271844 1 Pla2g4f|691907 1 LOC565386|565386 2 LOC565386 is uncharacterized and is orthologous to several paralogous mammalian clades. none 7 PLA2G5 P39877 5322 OrthoMCL14883 Pla2g5|18784 2 Pla2g5|29354 1 none 7 none 7 PLA2G6 O60733 8398 OrthoMCL4842 Pla2g6|53357 1 Pla2g6|360426 1 pla2g6|406370 2 none 7 PLB1 Q6P1J6 151056 OrthoMCL3499 Plb1|665270 2 Plb1|192259 2 none 7 PLB1|YMR008C; PLB2|YMR006C; PLB3|YOL011W 9 PMID: 10497163 PNPLA2 Q96AD5 57104 OrthoMCL4346 Pnpla2|66853 1 Pnpla2|361676 1 pnpla3|436610 2 Unreviewed protein. none 7 PTGDR Q13258 5729 OrthoMCL12914 Ptgdr|19214 1 Ptgdr|498475; Ptgdrl|63889 5 Rat Ptgdr and Ptgdrl are equally close to human PTGDR in P-POD, and both proteins have the same p-value in IMP. none 7 none 7 PTGDR2/GPR44 Q9Y5Y4 11251 OrthoMCL15034 Gpr44|14764 1 Gpr44|309212 2 none 7 One ortholog has been removed from Ensembl. none 7 PTGDS P41222 5730 OrthoMCL4269 Ptgds|19215 1 Ptgds|25526 1 ptgdsa|555483;ptgdsb|336492 6 P-POD identifies 3 orthologs: ptgsb plus 2 predicted or provisional genes. IMP identifies ptgsa and -b, but ptgsa has a better p-value. none 7 PTGER1 P34995 5731 OrthoMCL18609 Ptger1|19216 1 Ptger1|25637 1 none 7 none 7 PTGER2 P43116 5732 OrthoMCL7165 Ptger2|19217 1 Ptger2|81752 1 ptger2a|393608 6 P-POD also identifies ptger2b (NCBI GeneID 570410) as an ortholog of hPTGER2. none 7 PTGER3 P43115 5733 OrthoMCL11562 Ptger3|19218 1 Ptger3|24929 1 ptger3|100000544 2 none 7 PTGER4 P35408 5734 OrthoMCL8697 Ptger4|19219 1 Ptger4|84023 2 ptger4a|562469;ptger4b|100005416 8 none 7 PTGES O14684 9536 OrthoMCL11159 Ptges|64292 1 Ptges|59103 1 ptges|544666 1 none 7 PTGES2 Q9H7Z7 80142 OrthoMCL5306 Ptges2|96979 1 Ptges2|311865 2 ptgesl|799964 2 none 7 PTGES3 Q15185 10728 OrthoMCL2110 Ptges3|56351 1 P-POD identifies an additional mouse pseudogene. UniProt identifier for Ptges3 maps to 3 NCBI Gene IDs, but 2 are deprecated or pseudogenes. Ptges3|362809 1 ptges3a|406449 1 none 7, 9 ortholog SBA1 shares chaperone activity with PTGES3 but is not a prostaglandin synthase; PMID: 9584173 functional complementation: human gene PTGES3 complemented a yeast sba1 mutation for chaperone activity in vivo PTGFR P43088 5737 OrthoMCL11573 Ptgfr|19220 1 Ptgfr|25652 2 ptgfr|571808 2 A second locus, LOC100005681, is possibly a duplicate of ptgfr; it is also nearby. none 7 PTGIR P43119 5739 OrthoMCL11931 Ptgir|19222 1 Ptgis|25527 1 ptgir|561406 2 none 7 PTGIS Q16647 5740 OrthoMCL15316 Ptgis|19223 1 Ptgis|25527 1 ptgis|559148 2 none 7 PTGR1 Q14914 22949 OrthoMCL339 Ptgr1|67103 2 Ptgr1|192227 1 ptgr1|494108 1 none 7 The closest yeast gene is a paralog that is orthologous to another human gene. PTGS1 P23219 5742 OrthoMCL2837 Ptgs1|19224 1 Ptgs1|24693 1 ptgs1|246226 1 none 7 PTGS2 P35354 5743 OrthoMCL2837 Ptgs2|19225 1 Ptgs2|29527 1 ptgs2a|246227 8 Both P-POD and IMP identify both ptgs2a (NCBI GeneID 246227) and ptgs2b (NCBI GeneID 559020), but ptgs2a has a much better p-value in IMP. none 7 SLC27A2 O14975 11001 OrthoMCL2420 Slc27a2|26458 1 Slc27a2|65192 2 slc27a2|449925;slc27a2b|100004228 6 IMP identifies slc27a2, but the p-value is not very strong (3e-3). P-POD identifies slc27a2b plus 2 other predicted/provisional proteins. FAT1|YBR041W;FAA1|YOR317W;FAA4|YMR246W 3, 9 PMID:24269233 human gene SLC27A2 complemented the deficient SPH-to-glycerophospholipid metabolism in Δfaa1 Δfaa4 cells SOAT1 P35610 6646 OrthoMCL5372 Soat1|20652 1 Soat1|81782 2 soat1|564424 2 ARE1/YCR048W; ARE2/YNR019W 9 PMID: 8798656; sterol esterification TBXA2R P21731 6915 OrthoMCL14971 Tbxa2r|21390 1 Tbxa2r|24816 2 none 7 One ortholog in P-POD has been deprecated. none 7 TBXAS1 P24557 6916 OrthoMCL9695 Tbxas1|21391 1 Tbxas1|24886 1 tbxas1|792041 1 none 7